Acetaminophen-CAS 103-90-2
What is Paracetamol ?
Paracetamol is a medicine that exerts analgesic (reduces pain) and antipyretic (reduces fever) activity, but does not possess anti-inflammatory activity.
Name: Paracetamol
Synonyms: Acetaminophen, Acetamidophenol
C.A.S NO. : 103-90-2
Molecular formula: C8H9NO2
Molecule weight: 151.16
Specification: HPLC 99%
Characteristic: White ot off-white crystalline powder
Boiling point: 387.8±25.0 °C at 760 mmHg
Melting point: 168-172°C
| Tests | Standards | Results |
| Appearance | White or almost white,crystalline powder. | White,crystalline powder. |
|
Identification |
A:IR absorption | Complies |
| B:UV absorption | Complies | |
| C:TLC | Complies | |
| Melting point | 168~172℃ | 169.0~170.9°C |
| Water | Not more than0.5% | 0.0008 |
|
Related substance |
ImpurityJ(chloroacetanilide)not more than 10 ppm | 2ppm |
| Impurity K(4-aminophenol)not more than 50 ppm | 15 ppm | |
| Impurity F(4-nitrophenol)not more than 0.05% | Not detected | |
| any other impurity not more than 0.05% | 0.0001 | |
| Total of other impurities not more than 0.1% | 0.0002 | |
| Residue on ignition | Not more than 0.1% | 0.0005 |
| Chloride | Not more than 0.014% | Less than 0.014% |
| Sulfate | Not more than 0.02% | Less than 0.02% |
| Sulfide | Conforms | Conforms |
| Heavy metals | Not more than 0.001% | Less than 0.001% |
| Free p-aminophenol | Not more than 0.005% | Less than 0.005% |
| Limit of P-chloroacetanilide | Not more than 0.001% | Less than 0.001% |
| Readily carbonizable substances | Conforms | Conforms |
|
Residual solvents |
Residual content of acetic acid is limited by the test of loss on dryingnot more than0.5% |
0.0008 |
| Assay(anhydrous basis) | 99.0~101.0% | 0.996 |
| Conclusion | Complies with USP34/ BP2011 | |
Function
Paracetamol powder nutritional supplemen Mainly used for amino acid infusion,due to special wettability, also used in cold cream,osmetics. Serine constitute the human body of several kinds of essential amino acid of protein a, for the construction of protein has a very important role.
Application
Paracetamol is approved for reducing fever in people of all ages.
Paracetamol is used for the relief of pains associated with many parts of the body. It has analgesic properties comparable to those of aspirin, while its anti-inflammatory effects are weaker. It is better tolerated than aspirin in patients in whom excessive gastric acid secretion or prolongation of bleeding time may be a concern.
